How Olanzapine use can lead to death!
Before psych meds, I was 117 pounds of lithe muscle from regular judo. I was very healthy. Cholesterol was 133 with "good cholesterol" at 63! Because of an episode of disassociation, I was sent to a psychiatrist and eventually was diagnosed bipolar and put on a mood stabilizer resulting in rapid weight gain. Zyprexa was then prescribed at an ER visit. It worked. But it should not- in my opinion- be used as a maintenance drug. I was on zyprexa for something like two years and in that time it made me gain a ton of weight, trashed my blood sugar, blood pressure, cholesterol, triglycerides, and metabolism and gave me a serious case of fatty liver disease- all of which could kill me but especially the fatty liver as by the time we found it, it was advanced. I was getting close to more than just fat- it was progressing toward cirrhosis which will kill your liver- and you. So yeah- ive been off zyprexa a while but its gonna take hard work to reverse what its done to me.
Quotes I found with a simple search on Zyprexa and anti-psychotics in general:
Before psych meds, I was 117 pounds of lithe muscle from regular judo. I was very healthy. Cholesterol was 133 with "good cholesterol" at 63! Because of an episode of disassociation, I was sent to a psychiatrist and eventually was diagnosed bipolar and put on a mood stabilizer resulting in rapid weight gain. Zyprexa was then prescribed at an ER visit. It worked. But it should not- in my opinion- be used as a maintenance drug. I was on zyprexa for something like two years and in that time it made me gain a ton of weight, trashed my blood sugar, blood pressure, cholesterol, triglycerides, and metabolism and gave me a serious case of fatty liver disease- all of which could kill me but especially the fatty liver as by the time we found it, it was advanced. I was getting close to more than just fat- it was progressing toward cirrhosis which will kill your liver- and you. So yeah- ive been off zyprexa a while but its gonna take hard work to reverse what its done to me.
Quotes I found with a simple search on Zyprexa and anti-psychotics in general:
"The alterations seen in glucose metabolism include hyperglycemia, type 2 diabetes mellitus, or diabetic ketoacidosis and coma; whereas hypercholesterolemia, hypertriglyceridemia, and low high-density lipoprotein cholesterol level are possible lipid abnormalities associated with antipsychotic use."
Metabolic Monitoring of Antipsychotic Medications: What Psychiatrists Need to Know 1.
Metabolic Monitoring of Antipsychotic Medications: What Psychiatrists Need to Know 1.
"Although OLZ has a lower discontinuation rate and a greater reduction in psychopathology, (7, 8), it is associated with significant weight gain in patients (8–13), contributing to increased metabolic dysfunction, dyslipidemia, overweight/obesity, type II diabetes mellitus, heart disease, and mortality (14, 15)."
Olanzapine metabolism and the significance of the UGT1A448V and UGT2B1067Y variants 2.
"Thirdly, antipsychotic drugs indirectly affect the liver by increasing the risk of metabolic syndrome, leading to an increased risk of non-alcoholic fatty liver disease.[9] "
Antipsychotic Drugs and Liver Injury 3.
"Nonalcoholic fatty liver disease is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of nonalcoholic fatty liver disease is too much fat stored in liver cells.
"Nonalcoholic steatohepatitis, a potentially serious form of the disease, is marked by liver inflammation, which may progress to scarring and irreversible damage. This damage is similar to the damage caused by heavy alcohol use. At its most severe, nonalcoholic steatohepatitis can progress to cirrhosis and liver failure." 4.
Nonalcoholic fatty liver disease - Symptoms and causes - Mayo Clinic
I knew these effects were all related- I just never sewed them together. Lots of references in the links.
See also:
Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research
https://bipolarhallucidations.blogspot.com/2018/08/drs-uncover-cause-of-antipsychotic.html?m=0
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