Lithium Causes Hypothyroidism

"Lithium has been used in the treatment of acute bipolar mania for over 50 years, and has demonstrated superiority over placebo in several controlled clinical trials.16 In these studies, the percentage of patients showing at least moderate improvement after 2 to 3 weeks of treatment ranged from 40% to 80%. Lithium appears to be most, effective in patients with classic (euphoric) mania, while response rates are relatively poor in mixed states or rapid cycling.17

"Drawbacks of lithium therapy include its narrow therapeutic index (recommended plasma level 0.8 to 1.2 mmol/L), poor tolerability, especially at higher doses, and risk of “rebound mania” on withdrawal.18 Common side effects of lithium are tremor, polydipsia, polyuria, and, in the long term, hypothyroidism. Despite these shortcomings, lithium retains a role as a first-line treatment and is widely seen as the gold-standard comparator for newer agents, not to say that it may have antisuicidal effects.19,20 Lithium also been evaluated in relation to other antimanic agents. Head-to-head comparisons with antipsychotic drugs (usually chlorpromazine) have generally found lithium to be superior in terms of overall improvement in symptoms, mood, and ideation, but worse with respect to motor hyperactivity and onset of action. Lithium was as efficacious as quetiapine in a 12-week, randomized, double-blind trial21 In a three-arm randomized study comparing placebo, lithium, and valproate, lithium and valproate were similarly effective in improving manic symptoms.22"

From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181868/#ref17

God Told Me the Meaning of the Universe!

My revved up feeling has turned into no sleep and exhaustion- but I can't stop. I just had a conversation with a guy that Ive seen lots of times before but we just said hi or are you leaving this seat? Anyway, we talked a long time about lots of things. I couldn't stop yapping. I just kept talking despite my better judgement- well who's kidding who?- that flew out the window. I just kept talking and things came out of my mouth that now I am worried he's going to stalk me and kill me and my kids! I stayed up until 3 ish last night watching the same movie over and over. I constantly have infinite energy while at the same time feel the need to crash in the middle of the day for a third time this week. Day after day I repeat this pattern: talk too much about things I shouldn't be saying at all at whoever is willing to listen. I can't stop until I am forced to. I've also spent all my money in the last week. My account is overdrawn, actually. 

Despite all of this, I don't care! Eh, whatever! God has taken all my worries away- what a gift it truely is. Jesus is Lord! He told me the meaning of my entire life and that the universe and I are one now and forever just like his love. I know all.

Eli Lilly makers of Zyprexa Try to Hide Side Effects

"...as early as 1998, Lilly considered the risk of drug-induced obesity to be a "top threat" to Zyprexa sales."

"Eli Lilly has faced many lawsuits from people who claimed they developed diabetes or other diseases after taking Zyprexa, as well as by various governmental entities, insurance companies, and others. Lilly produced a large number of documents as part of the discovery phase of this litigation, which started in 2004; the documents were ruled to be confidential by a judge and placed under seal, and later themselves became the subject of litigation.^[104]

In 2006, Lilly paid $700 million to settle around 8,000 of these lawsuits,^[105] and in early 2007, Lilly settled around 18,000 suits for $500 million, which brought the total Lilly had paid to settle suits related to the drug to $1.2 billion.^[106][107]

[106]^[107]

"A December 2006 New York Times article based on leaked company documents concluded that the company had engaged in a deliberate effort to downplay olanzapine's side effects.^[106][108] The company denied these allegations and stated that the article had been based on cherry picked documents.^[106][107] The documents were provided to the Times by Jim Gottstein, a lawyer who represented mentally ill patients, who obtained them from a doctor, David Egilman, who was serving as an expert consultant on the case.^[104] In 2007 Lilly filed a protection order to stop the dissemination of some of the documents, which Judge Jack B. Weinstein of the Brooklyn Federal District Court granted, and criticized the New York Times reporter, Gottstein, and Egilman in the ruling.^[104] The Times of London also received the documents and reported that as early as 1998, Lilly considered the risk of drug-induced obesity to be a "top threat" to Zyprexa sales.^[107] On October 9, 2000, senior Lilly research physician Robert Baker noted that an academic advisory board he belonged to was "quite impressed by the magnitude of weight gain on olanzapine and implications for glucose."^[107]

"Lilly had threatened Egilman with criminal contempt charges regarding the documents he took and provided to reporters; in September 2007 he agreed to pay Lilly $100,000 in return for the company’s agreement to drop the threat of charges.^[109]

"In September 2008 Judge Weinstein issued an order to make public Lilly's internal documents about the drug in a different suit brought by insurance companies, pension funds, and other payors.^[104]

"In March 2008 Lilly settled a suit with the state of Alaska^[110] and in October 2008, Lilly agreed to pay $62 million to 32 states and the District of Columbia to settle suits brought under state consumer protection laws.^[109]

"In 2009, Eli Lilly pleaded guilty to a US federal criminal misdemeanor charge of illegally marketing Zyprexa for off-label use and agreed to pay $1.4 billion.^[111][112]"

^{Quotes from and references:}  

^{https://en.m.wikipedia.org/wiki/Olanzapine}

Beep Boop!

Beep. Boop. Yup. Uh huh..... I am one with the universe and I know all the answers! Suck on THAT Einstein!

I'm Free!

I feel like I'm a car that's got the parking break stuck on and yet I'm pushing down the accelerator over and over. I've felt mildly nauseated for the last week- like I need to vomit.   Today is an absolutely gorgeous day!  Bright sunshine, blue sky with puffy white clouds, fifty degrees, slight breeze, trees are flowering and in bud, grass is green, flowers are up and bloomed... I am FREE!  Free of all the worry, angst, fear, aweful side effects from drugs.  There's a spring in my step, a dance is my shuffle, a whistle on my lips... I am care free.  Foot loose and fancy free!  My thoughts are abundant and they come to me with exacting ease.  I am a genius- God has given me this gift.  My life is one again!  How it was and how it SHOULD be!  All the experiences of my life joined as one- like a choir singing gregorian chant - in unison, separate entities joining as one being, the whole greater than the sum of its parts.

P.S.  A couple days this week, I've been so exhausted that I've laid down in the late afternoon and just CRASHED!  I slept like a kid after a long day of travel or play- over two hours SOLID after only just having laid my head on the pillow.

Delerious Mania- Mania on Steroids

I just read a case report of a man with delerious mania. Yes it is rare but of interest isn't the delerious part but the mania. They pumped so much medication into this guy! Again- they'd rather he not die immefiately so they'll just medicate the hell out of him. I hope this medication course was short-term- and that Depakote was all he remained on- although Depakote is a serious drug, in my opinion. They followed him out one year and then lost touch. We can't know what indefinite high doses of Depakote and several other psychiatric medications did to him. He also received several ECT treatments- bilaterally. This is an extreme case with extreme treatments that resolved quickly. One wonders what the lasting effects will be.

The following quotes are from https://www.hindawi.com/journals/crips/2012/720354/ 

Case Report

Delirious Mania: Can We Get Away with This Concept? A Case Report and Review of the Literature

Rajshekhar Bipeta1 and Majeed A. Khan1,2

"He presented with an acute onset, third episode, of ten-day duration, characterized by assaultive behaviour, incessant and boastful talk, excessive planning, overfamiliarity, increased sexual desire, and decreased need for sleep and food. He was continuously reciting from the holy books; his relatives saw no coherence in it; it was totally misplaced. He engaged in continuous charity, without any signs of stopping it. The symptoms increased in severity within the previous six hours."

And...

"Rapport could not be established. He was extremely agitated, cursing everybody, including the doctors, and spitting at others. He even assaulted the hospital staff. He was turning everything upside-down, pushing the hospital furniture, jumping on the bed, dragging the mattresses, destroying all that which was in his reach. He had to be tied securely to the cot, but was even pulling the cot. He was making sexual advances towards fellow patients and hospital staff. These prolonged periods of extreme agitation would be followed by brief periods of sudden calmness and muteness."

And...

"He was diagnosed to have “bipolar disorder I, most recent episodemanic, severe withpsychotic features” as per Diagnostic and Statistical Manual of Mental Disorders (DSM IV criteria) [24]. He had associated features suggestive of delirium."

And...

"The elevated BP was managed with atenolol 50 mg/day. He was started on divalproex 1000 mg/day, haloperidol 20 mg/day, and lorazepam 4 mg/day. On day 2, as he was still very disturbed, olanzapine 10 mg i/m was administered. As there was no relief even after 8 hours, zuclopenthixol (Acuphase) 100 mg i/m was given, and loxapine (an antipsychotic drug) 25 mg/day was added."

And...

"By day 3, there was no relief; however, sleep was better. Loxapine was increased to 50 mg/day. By day 4, the aggression was better and clinically he was “much improved.” He was now sleeping from 6 to 7 hours per night. Divalproex was increased to 1500 mg/day, and haloperidol was discontinued.

"By day 5, as the BP was under control (130/90 mm Hg), bilateral ECT was started. The patient was maintaining the same improvement at day 7. He would quietly lie down, paranoia was coming down and he started accepting food and water. He was now amenable to suggestions and started calling others with respect. Loxapine was increased to 100 mg/day. By day 10, the patient had shown “marked improvement” and there was no evidence of any psychopathology. His self-care improved. His insight was relatively improved, the consciousness was clear and he was well oriented. Divalproex was increased to 2000 mg/day.

"A total of four sessions of ECT were administered. On day 12 (day of discharge), there was “marked improvement with no side effects.” He did not remember what had happened till one day back, for the previous nineteen days..."

Why am I Not Dead Yet??

Over the last week, I've started posting on this blog again- my pdoc thinks that's always a bad sign when I do that, but I've had so many awesome ideas and discoveries, I have to get them down. The last week, I figured out why and how antipsychotics are killing me. 

With or without meds, I still hallucinate, have delusions, get hypo/mania and sometimes depression. (Recently, I thought people were in my walls so I hid under the covers in my room. Yes I did - at 47!) Meds have trashed my physical health over the years. I have a list "this long" from a checkout report after I saw my primary doctor recently. (See below.)  It includes my "list of complaints"- all the things wrong with me currently- all of my current diagnoses. To read it, you'd think "Geeze! Why hasn't she just dropped dead already?" I attribute these back to one thing: psych meds. (Obese, high blood pressure, high blood sugar... )For instance, lithium carbonate trashed my thyroid. I now have big nodules, hypothyroidism and a metabolism that's in the toilet. Moreover, Zyprexa gave me fatty liver disease and by the time we found it, it was pretty advanced. I'm desperately trying to diet and exercise to reverse this- but its still there and Ive been off zyprexa and Lithium Carbonate for quite a bit now. 

These are not all my complaints but today I really don't feel good physically- haven't for several days.

List of medical problems according to my primary doctor:

1. Pulmonary embolism [twice], will need life long anticoagulation. (12/18/2005), no known cause.  Possibly side effect from surgery. Treatment: life-long anticoagulant use.

2. Migraine headache. (3/12/2008), Known cause:  triggers such as caffeine withdrawal, weather changes, many others. Treatment: Tegretol (intractable migraine/pain admin. by medical professional only)  infrequent) and Sumatriptan (As needed.  Doesn't work as well as Tegratol.)

3.  Hypothyroidism and multinodular goiter. (Unknown).  Possible cause: Years of treatment with Lithium Carbonate- mood stabilizer. Effects: Dry, itchy skin, Extremely slow metabolism; disturbance of many bodily functions (including metabolism) which rely on both T3 and T4, extreme tiredness, others. Treatment: T4 replacement (Levoxyl).

4. Obstructive sleep apnea, adult.  Effects: Frequent low oxygen saturation levels, heart disease/palpatations, feeling of being unrested, falling asleep while driving.  Cause: repeated obstruction of airway due to excessive fat in the throat, weight gain linked to long-term antipsychotic use.  Treatment: weight losse; Use of CPAP/BiPap.

5. Food allergy- specifically, seafood.  Effects: anaphylaxis.  Cause: unknown.  Treatment: Epipen, Benedryl, avoid allergen.

6.  Thyroiditis, lymphotic.  Cause: Hypothyroidism/ling-term use of Lithium Carbonate (Mood stabilizer.) 

7.  Anxiety disorder.  Cause: situational; part of bipolar disorder; treatment: benzodiazepine (discontinued), Dialectical Behavioral Therapy.  

8.  Schizoaffective disorder, bipolar type. (11/2013- and earlier/no date).  Cause: childhood and/or adult trauma possible; genetics; unknown other factors.

8a.  Bipolar 1 disorder.  (2005- present.)  See "8. Schizoaffective disorder, bipolar type.

9. Metabolic syndrome. Cause: High blood pressure, high blood sugar, and obesity.  Effects: Extremely slow metabolism, risk of stroke, risk of heart attack, exacerbated obesity and negative effects of such the afforementioned, - causes: atypical antipsychotics, especially Clozaril and Zyprexa (Olanzapine).

10.  Akathesia. (2014/2018) (Uncontrollable muscle movements. Frequent and continuous.  See "7. Anxiety Disorder.)  Cause: side effect to various antipsychotics.) Treatment: benzodiazepines.  Removal/decrease of mood antipsychotic. 

11. Hypercalcemia.  (2016)

12. Colon adenoma.  (2016).  

13. Dysphonia. (2018).  Affects vocal cords; difficulty talking and singing. Cause: unknown. Treatment: voice therapy. 

14.  Vocal cord paralysis, unilateral partial. Treatment: none.  Cause: unknown.

15.  Mild intermittent asthma without complication. (1988- present).  Cause, unknown.  Exposure to allergens to pet dander, seasonal allergies, cigarette smoke, perfume, certain foods and MSG; others. Treatments: albuterol rescue inhaler, steroid inhaler (preventaive).  Possible: hospital treatment if episode is severe.  

16.  Essential hypertension.  (2018).  Complications: heart attack; stroke.  Cause: obesity brought on my antipsychotics, especially Zyprexa (Olanzapine.)

17. Fatty liver disease.  (2017?) (Elevated liver enzymes)  Cause: obesity.  Fat in the liver, brought on by rapid weight gain, especially due to long-term use of Zyprexa (Olanzapine).  Complications: cirrhosis of the liver; death.

OVERALL TREATMENT:

Regular exercise (3/4 times a week); diet changes (Fewer calories, more fiber, protein and fresh vegetables and fruits.)  Possible discontinuation/ replacement of offending medications.  Get vitals checked often; keep doctor appointments.

I Want my Real Life Back!

The last week, Ive been exercising a lot more and trying to eat well.  I feel GREAT!  Ive been posting almost everyday in this blog- one theme about antipsychotics and side effects.  My health is TERRIBLE on paper and I simply can't just wait to die from the "side effects" from these drugs.  I feel like my head has cleared out- like its been rinsed out with mouthwash- aahhh! I can THINK again!  My thoughts just come to me easily and don't search for words.  (I used to do this as a matter of course- day in, day out.)  I cannot wait for anti psychotics to kill me, living every day substandardly.  My bipolar symptoms are with me even when I take the pills regularly.  Mania, hypomania, paranoia, hallucinations and delusions- had 'em all.  Almost every psych med Ive been prescribed has not worked simply because the side effects are bad enough that my psych nurse practitioner couldn't NOT take me off. And those are the "loud" bad effects.  The "silent" ones- like high blood pressure, fatty liver disease, excessive weight gain, pre-diabetes, etc are just as real but why are they tolerated- by my psych nurse, primary doctor and ESPECIALLY ME? Bipolar will kill me alright- but the actual treatments will be responsible, not the effects of my disease. 

Before I was diagnosed, life was good!  I was extremely fit, physically and medically.  I never had these symptoms - no side effects.  In a short period, all that changed.  Now I can't kill the cycle of feeling ill physically and contastantly chasing "sanity", in and out of the doctors- psych nurse because I get "too happy", and my long-time primary doctor who chases after my psych meds like crazy- including sleep apnea from the extreme weight gain (that can kill you too!)- cleaning up all the (side) effects with more tests, and lots of medications to undo what antipsychotics have turned me into.

I don't think Ive ever truely been manic- at least not in the extreme.  Ive thought I'd figured out the meaning to my life, yeah, but what's the harm in that? Everybody wishes for that at some point in their lives.  When I'm talkative and clever and funny and creative and quick-witted, that's ME!  The me I have always been.  I feel myself, free and devoid of the med rollercoaster, diagnosis codes, especially psych hospitals and my communication with my kids is exciting and yet educational- on both sides!

Why should I contasntly live burdoned by the medication rollercoaster- with fear, worry, drug side effects and the incessant anxiety/fear that I will simply melt into this rotting stew that is my new bipolar life?  That is no way to spend my midlife and on.

This all needs to be rethought.  I want my life back to age 33 when life was devoid of even KNOWING the term "bipolar", judo was my passion, where judo and great sex kept the endorphines running and my body was strong, lithe and healthy.  Period.

Zyprexa, Metabolic Disfunction & Diabetes/ How Zyprexa can Kill You Part 2

Zyprexa associated with the highest incidence of metabolic disfunction.

Zyprexa and diabetes: Its not just that you're fat!  

From the following article: https://www.pharmacytimes.com/publications/issue/2012/march2012/olanzapine-and-clozapine-atypical-antipsychotic-induced-type-2-diabetes-

"Olanzapine and clozapine have the highest affinity for H1 receptors and are associated with the greatest weight gain; ziprasidone and aripiprazole have the lowest affinity for H1 receptors."

And....

"Some patients develop diabetes without concomitant changes in BMI, however; therefore, there must be other possibilities aside from the weight gain. One possible mechanism involves alterations in pancreatic beta-cells, specifically antagonism of pancreatic adrenergic alpha 2 receptors, 5-HT1 alpha receptors, and/ or muscarinic M3 receptors. When these receptors are blocked, the beta-cells in the pancreas lose the ability to respond to changes in blood glucose levels. Another possibility involves alterations in glucose transporters on hepatic and skeletal muscle tissue. When these transporters are inhibited, glucose cannot get to target tissue and high levels of glucose remain in the blood.9 This is not a complete list of possible mechanisms; there is much more work to be done to fully explain why atypical antipsychotic medications induce type 2 diabetes."

Also,

"If there is a rise in triglycerides or weight gain, a switch to another agent, such as ziprasidone or aripiprazole, should be considered, and the patient should continue to be monitored. If a patient has dyslipidemia, pre-diabetes, or diabetes prior to initiating antipsychotic medication, it is recommended to avoid high-risk medications such as olanzapine and clozapine and to watch for signs and symptoms of diabetic ketoacidosis/hyperglycemic hyperosmolar syndrome.11"


"Of the atypical antipsychotics, clozapine and olanzapine are associated with the highest incidence of metabolic disfunction, whereas ziprasidone and aripiprazole are considered to be the least risky."


"

Just the Ones They Can't Sell

Last summer, I was having dinner with my kids.  I got up and went to the kitchen to get more drink and took my plate with me.  Once in the kitchen, I abruptly dropped my food onto the linoleum floor.  Crash!  My then-18-year-old daughter ran in to see what was happening.  Earlier, my (then) 16-year-old son had stopped me from running a stop sign and hitting someone!   He had to yell "Mother!" quickly and loudly so I'd hit the brakes hopefully quickly enough.  After I'd dropped my food, my daughter said "I'm taking you to the hospital!"

So off we went in her car.  We ended up in the psych emergency services.  They asked me a bunch of questions, including who the president was.  I think I said "Eisenhower!" but frankly that day was kind of a blur.  I wasn't kidding either.  I felt "off" but I was REALLY off!  The PES diagnosed me with delerium and made steps to quickly transfer me to the regular ER.

Once there, they put me in a room right away.  The only thing I can remember is being in that room, my whole body shaking uncontrollably.  My arms especially were shaking "big"- very fast and above my body.  By this time a lot of medical type people were in the tiny room with me.  Alarms were going off on my vitals monitor.  I couldn't move voluntarily.  I lay there amidst the cacophony of alarms and silent blank stares from everybody that filled my tiny room, unable to do anything except to stare straight ahead of me blindly while I had this whole-body seizure-like event.  This went on for what seemed like forever.  More people squeezed in to look from the hallway.

I don't know what happened next.

My lithium blood levels were taken.  This is done at regular intervals by psychiatrists to keep an eye on these levels.  Mine were "sky high"!  I was diagnosed with Lithium Toxicity.

I do not know what they did to treat me.  I was taken off lithium completely right then and there.

My psych nurse practitioner called me once I was finally home again and appologized profusely.  She should've taken a lithium level the day she saw me, she said.  Well who knew?  I didn't.  Your body can react to the drug differently suddenly and the Lithium in your blood goes up.  There is a fine line between a level that is theraputic and one that is not.  This is why it is monitored closely.

I have never taken Lithium again and I never will.  Psych meds are no joke.  They are powerful chemicals with serious side affects.  They affect the whole body, not just one part of your brain- or even ALL of your brain.

These types of events aren't as rare as we think.  As my good friend has said, "Side effects aren't "side" effects.  They're just the ones pharmaceutical companies can't sell."

That's it!!

I have been in remission for several months now.  Its wonderful!  Ah! Life!  I feel like me again.  I've been eating well and exercising regularly.  The lack of all that crap is such a relief! Its been too long taking umpteen meds that have horrible side effects and a lot of the time don't really make a difference.  

I had a coffee around noon but without my usual cereal. By 2:00 when I got to my mom's for Easter dinner, my blood sugar tanked. Then dinner was over an hour late. I ate a modest meal and no 2nd helpings. Now I still feel blah. No exercise today because of the blah feeling. But bipolarwise I'm fine. No anxiety, depression, hypo/mania, hallucinations or delusions. In fact I feel like I did back before I was diagnosed bipolar- back when I was doing judo regularly and eating well.  No side effects from meds because I wasn't taking them.  As a matter of fact, I was diagnosed bipolar at the same time as I got blood clots in my lungs and had to quit judo!  I'd had very few bipolar symptoms at that point and no hospitalizations.  I also started Depakote- my very first bipolar med- right after diagnosis.  (Years later, I was changed to Zyprexa- a notorious severe weight-gainer) and gained even more.  I was on zyprexa for YEARS!  It raised my blood sugar and gave me pre-diabetes, I have high blood pressure now, and have had cholesterol in the 700's.  (Normal is below 200.  I was at 133 before psych meds.) As I posted the other day, I have had fatty liver disease for at least a year and all I get is more meds to cover these very real effects from years of regular antipsychotic use.  I will not fight against these psych meds anymore. They are slowly killing me and nobody cares except my liver doctor. I have 4 months until I see him again and I'll be damned if I'm going to sit around waiting to die a premature death any longer. That's it. Diet and exercise is the way to true happiness.

"Killing My Body to Save My Mind"

https://www.elle.com/beauty/health-fitness/advice/a11743/gaining-weight-to-cure-depression/

Killing My Body To Save My Mind

A woman takes Zyprexa to cure depression and finds herself with metabolic syndrome and 80 pounds heavier.

Sound familiar?

How Zyprexa (and other anti-psychotics) Can Kill You

How Olanzapine use can lead to death!

Before psych meds, I was 117 pounds of lithe muscle from regular judo.  I was very healthy.  Cholesterol was 133 with "good cholesterol" at 63!  Because of an episode of disassociation, I was sent to a psychiatrist and eventually was diagnosed bipolar and put on a mood stabilizer resulting in rapid weight gain.  Zyprexa was then prescribed at an ER visit.  It worked.  But it should not- in my opinion- be used as a maintenance drug.  I was on zyprexa for something like two years and in that time it made me gain a ton of weight, trashed my blood sugar, blood pressure, cholesterol, triglycerides, and metabolism and gave me a serious case of fatty liver disease- all of which could kill me but especially the fatty liver as by the time we found it, it was advanced. I was getting close to more than just fat- it was progressing toward cirrhosis which will kill your liver- and you. So yeah- ive been off zyprexa a while but its gonna take hard work to reverse what its done to me.

Quotes I found with a simple search on Zyprexa and anti-psychotics in general:

"The alterations seen in glucose metabolism include hyperglycemia, type 2 diabetes mellitus, or diabetic ketoacidosis and coma; whereas hypercholesterolemia, hypertriglyceridemia, and low high-density lipoprotein cholesterol level are possible lipid abnormalities associated with antipsychotic use."
Metabolic Monitoring of Antipsychotic Medications: What Psychiatrists Need to Know 1.

"Although OLZ has a lower discontinuation rate and a greater reduction in psychopathology, (7, 8), it is associated with significant weight gain in patients (8–13), contributing to increased metabolic dysfunction, dyslipidemia, overweight/obesity, type II diabetes mellitus, heart disease, and mortality (14, 15)."

Olanzapine metabolism and the significance of the UGT1A448V and UGT2B1067Y variants 2.

"Thirdly, antipsychotic drugs indirectly affect the liver by increasing the risk of metabolic syndrome, leading to an increased risk of non-alcoholic fatty liver disease.[9] "

Antipsychotic Drugs and Liver Injury 3.

"Nonalcoholic fatty liver disease is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of nonalcoholic fatty liver disease is too much fat stored in liver cells.

"Nonalcoholic steatohepatitis, a potentially serious form of the disease, is marked by liver inflammation, which may progress to scarring and irreversible damage. This damage is similar to the damage caused by heavy alcohol use. At its most severe, nonalcoholic steatohepatitis can progress to cirrhosis and liver failure." 4.

Nonalcoholic fatty liver disease - Symptoms and causes - Mayo Clinic

I knew these effects were all related- I just never sewed them together. Lots of references in the links.

See also:

https://www.hindawi.com/journals/cpn/2013/647476/

Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research 

https://bipolarhallucidations.blogspot.com/2018/08/drs-uncover-cause-of-antipsychotic.html?m=0

1. https://www.psychiatrictimes.com/psychopharmacology/metabolic-monitoring-antipsychotic-medications-what-psychiatrists-need-know

2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281394/

3.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925599/

4.

https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/symptoms-causes/syc-20354567